Pseudoangiomatous Stromal Hyperplasia (PASH) of the Breast With Foci of Morphologic Malignancy: A Case of PASH With Malignant Transformation?

Pseudoangiomatous stromal hyperplasia (PASH) is a benign proliferation of the hormonally responsive, specialized mammary stroma characterized by slit-like pseudovascular spaces lined by bland spindle cells. It is usually an incidental microscopic finding but in some cases it may present as a slowly...

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Bibliographic Details
Published in:International journal of surgical pathology 2010-12, Vol.18 (6), p.564-569
Main Authors: Nassar, Hind, Elieff, Michelle P., Kronz, Joseph D., Argani, Pedram
Format: Article
Language:English
Subjects:
Adult
Angiomatosis - pathology
Breast Diseases - pathology
Breast Neoplasms - pathology
Cell Transformation, Neoplastic
Female
Humans
Hyperplasia - pathology
Hypothyroidism - complications
Sarcoma - pathology
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Summary:Pseudoangiomatous stromal hyperplasia (PASH) is a benign proliferation of the hormonally responsive, specialized mammary stroma characterized by slit-like pseudovascular spaces lined by bland spindle cells. It is usually an incidental microscopic finding but in some cases it may present as a slowly growing mass. A malignant counterpart for this lesion has not been reported. We describe a case of PASH with foci of malignant histologic features presenting as a slowly growing mass in a 30-year-old woman. The previously reported variants of PASH and the other mammary stromal lesions related to PASH are also discussed. This is perhaps the first case of PASH with foci of malignant histologic features reported in the literature and represents a rare sarcoma derived from specialized hormonally responsive mammary stroma.
ISSN:1066-8969
1940-2465
DOI:10.1177/1066896908320835