Clinical course of a malignant peripheral nerve sheath tumor in a Siberian tiger (Panthera tigris altaica)

A 14-year-old male Siberian tiger (Panthera tigris altaica) was admitted with an ulcerating mass on the right thoracic wall. Radiographic and computed tomographic evaluation indicated 2 isolated cutaneous masses without any signs of metastasis. Histology of a Tru-Cut biopsy revealed an anaplastic sa...

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Bibliographic Details
Published in:Journal of veterinary diagnostic investigation 2010-11, Vol.22 (6), p.970-975
Main Authors: Steinmetz, Hanspeter W, Rutten, Maja, Ruess-Melzer, Katja, Ohlerth, Stefanie, Lischer, Christoph, Oevermann, Anna, Bode-Lesniewska, Beata, Hatt, Jean-Michel
Format: Article
Language:English
Subjects:
Animals
biopsy
computed tomography
domestic animals
giant cells
immunohistochemistry
Lung Neoplasms - secondary
lungs
Male
metastasis
Nerve Sheath Neoplasms - pathology
Nerve Sheath Neoplasms - veterinary
nerve tissue
Panthera tigris altaica
radiography
sarcoma
Sarcoma - pathology
Sarcoma - veterinary
Tigers
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Summary:A 14-year-old male Siberian tiger (Panthera tigris altaica) was admitted with an ulcerating mass on the right thoracic wall. Radiographic and computed tomographic evaluation indicated 2 isolated cutaneous masses without any signs of metastasis. Histology of a Tru-Cut biopsy revealed an anaplastic sarcoma with giant cells. Both tumors were resected with appropriate normal tissue margins. The size of the defect did not allow primary closure of the wound; therefore, a mesh expansion technique was attempted. Three months later, the tiger had to be euthanized due to extensive metastasis to the lungs. Histomorphological features and immunohistochemical results confirmed the diagnosis of malignant peripheral nerve sheath tumor. In contrast to domestic animal experience, the tumor had spread extensively to the lungs without local reccurrence in a short period of time. Correct diagnosis requires various immunohistochemical evaluations of the tumor tissue.
ISSN:1040-6387
1943-4936
DOI:10.1177/104063871002200621