"Rescue allocation offers" in liver transplantation: Is there any reason to reject "unwanted" organs?

• Published in: Scandinavian journal of gastroenterology 2010-12, Vol.45 (12), p.1516-1517
• Main Authors: Doenecke, Axel, Scherer, Marcus N., Tsui, Tung-Yu, Schnitzbauer, Andreas A., Schlitt, Hans-Jürgen, Obed, Aiman
• Format: Article
• Language: English
• Subjects: Biological and medical sciences; Donor Selection; Extended donor criteria; Gastroenterology. Liver. Pancreas. Abdomen; Humans; Liver Transplantation; Liver, biliary tract, pancreas, portal circulation, spleen; marginal donor; Medical sciences; Patient Selection; rescue allocation; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of the digestive system; Tissue and Organ Harvesting; Waiting Lists
• ISSN: 0036-5521; 1502-7708
• DOI: 10.3109/00365521.2010.510577

Abstract To increase the number of transplanted organs, the Eurotransplant foundation uses a so-called "rescue-organ-allocation" procedure for organs that had been rejected by at least three consecutive transplant centers for medical reasons. The transplant center that finally accepts such an organ can then freely choose a patient from its own waiting list, without being bound to regular allocation criteria. Almost 30% of deceased donor livers are now allocated through this process in the Eurotransplant region. We report our results of 38 "rescue-allocation" livers (RA livers) transplanted at our institution (2003-2007), compared to a group of 115 regularly allocated organs within the same period. From our data, RA livers have the same results as regularly allocated livers. Type and frequency of postoperative morbidity did not differ between both groups, though the analysis of subgroups showed a tendency toward reduced survival of RA livers in patients with viral hepatitis. Interestingly, the Donor Risk Index (DRI) showed no difference between RA livers and regularly allocated livers. Although preliminary due to small numbers, we conclude that RA livers can be safely transplanted without increased mortality or morbidity. However, no donor specific criteria which would justify rejecting a RA liver were found. This highly challenges the applicability of the RA procedure in its current form.