Amoxapine elevates serum prolactin in depressed men

It has been suggested that the antidepressant amoxapine might have neuroleptic properties. Clinically, an increase in serum prolactin occurs during neuroleptic treatment secondary to post-synaptic dopamine blockade. Ten men who met DSM-III criteria for major depression exhibited a significant increa...

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Bibliographic Details
Published in:Journal of affective disorders 1983-11, Vol.5 (4), p.305-310
Main Authors: Anton, Raymond F., Sexauer, James D., Randall, Carrie L.
Format: Article
Language:English
Subjects:
Amoxapine - therapeutic use
Biological and medical sciences
Bipolar Disorder - blood
Bipolar Disorder - drug therapy
Depressive Disorder - blood
Depressive Disorder - drug therapy
Desipramine - therapeutic use
Dibenzoxazepines - therapeutic use
Humans
Male
Medical sciences
Middle Aged
Neuropharmacology
Pharmacology. Drug treatments
Prolactin - blood
Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
Receptors, Dopamine - drug effects
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Summary:It has been suggested that the antidepressant amoxapine might have neuroleptic properties. Clinically, an increase in serum prolactin occurs during neuroleptic treatment secondary to post-synaptic dopamine blockade. Ten men who met DSM-III criteria for major depression exhibited a significant increase in their serum prolactin over drug-free baseline values during treatment with amoxapine. A comparison group of 12 depressed men treated with desipramine showed no such increase. Combined with that of others, our study suggests that amoxapine might have antipsychotic properties and, therefore, be useful in treating conditions where a combined antidepressant and neuroleptic effect is required.
ISSN:0165-0327
1573-2517
DOI:10.1016/0165-0327(83)90020-4