Herpesvirus saimiri. V. Further Evidence to Consider This Virus as the Etiological Agent of a Lethal Disease in Primates Which Resembles a Malignant Lymphoma

Herpesvirus saimiri, a new herpesvirus indigenous to the squirrel monkey (Saimiri sciureus), with the ability to induce malignant lymphoma in nonhuman primates has been reisolated from kidney tissue cultures prepared from the affected animals at the terminal stage of disease. The purity of the reiso...

Full description

Saved in:
Bibliographic Details
Published in:JNCI : Journal of the National Cancer Institute 1970-05, Vol.44 (5), p.1175-1181
Main Authors: Meléndez, L. V., Daniel, M. D., Hunt, R. D., Fraser, C. E. O., Garciá, F. G., King, N. W., Williamson, M. E.
Format: Article
Language:English
Subjects:
Animals
Autopsy
Cell Nucleus
Cornea
Culture Techniques
Female
Haplorhini
Herpesviridae - isolation & purification
Herpesvirus 1, Cercopithecine - isolation & purification
Kidney Neoplasms - microbiology
Kidney Neoplasms - pathology
Liver Neoplasms - microbiology
Liver Neoplasms - pathology
Lymphoma - microbiology
Lymphoma - pathology
Male
Microscopy, Electron
Neoplasms, Experimental - microbiology
Neoplasms, Experimental - pathology
Ultracentrifugation
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Herpesvirus saimiri, a new herpesvirus indigenous to the squirrel monkey (Saimiri sciureus), with the ability to induce malignant lymphoma in nonhuman primates has been reisolated from kidney tissue cultures prepared from the affected animals at the terminal stage of disease. The purity of the reisolated H. saimiri was determined by filtration, reinoculation in susceptible animals, and by electron microscopy. These studies indicate that H. saimiri fulfills Koch's postulates for the experimentally induced lethal disease characterized histologically as a type of malignant lymphoma in nonhuman primates.
ISSN:0027-8874
1460-2105
DOI:10.1093/jnci/44.5.1175