Surface Morphology of Human Leukocytes

Surface morphology of individual leukocytes was correlated with their light microscopic appearance by a simple, direct technique. Circulating leukocytes of all types were roughened spheres with diameters similar to red cells, and leukocyte types could not be distinguished consistently by surface mor...

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Bibliographic Details
Published in:Blood 1971-01, Vol.37 (1), p.23-30
Main Authors: Michaelis, Thomas W., Larrimer, Nye R., Metz, Earl N., Balcerzak, Stanley P.
Format: Article
Language:English
Subjects:
Cell Membrane
Cell Nucleus
Humans
Latex
Leukocytes - cytology
Microscopy, Electron
Microscopy, Electron, Scanning
Microspheres
Phagocytosis
Surface Properties
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Summary:Surface morphology of individual leukocytes was correlated with their light microscopic appearance by a simple, direct technique. Circulating leukocytes of all types were roughened spheres with diameters similar to red cells, and leukocyte types could not be distinguished consistently by surface morphology. After surface contact, leukocytes in creased in diameter and exhibited a variety of projections. Cells spread on surfaces could be identified by external morphology. Several stages in the phagocytosis of latex particles were demonstrated. The study of surface contours by scanning electron microscopy represents a new approach to morphology.
ISSN:0006-4971
1528-0020
DOI:10.1182/blood.V37.1.23.23