Preparation and characterization of [ 99 mTc(DMPE) 2X 2] +, X = Cl, Br (DMPE = 1,2-bis (dimethylphosphino)ethane)

The preparation of “no-carrier-added” [ 99 m Tc(DMPE) 2X 2] + ( X = Cl, Br) in greater than 95% radio-chemical purity, suitable for in vivo evaluation as a myocardial imaging agent, is described. Reaction parameters that lead to the formation of the desired products, as well as those that lead to th...

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Bibliographic Details
Published in:The International journal of applied radiation and isotopes 1983-12, Vol.34 (12), p.1611-1618
Main Authors: Vanderheyden, Jean-Luc, Libson, Karen, Nosco, Dennis L., Ketring, Alan R., Deutsch, Edward
Format: Article
Language:English
Subjects:
Animals
Chemistry
Chromatography, High Pressure Liquid
Coordination compounds
Dogs
Exact sciences and technology
Heart - diagnostic imaging
Inorganic chemistry and origins of life
Organotechnetium Compounds
Phosphines - chemical synthesis
Preparations and properties
Radionuclide Imaging
Technetium - chemical synthesis
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Summary:The preparation of “no-carrier-added” [ 99 m Tc(DMPE) 2X 2] + ( X = Cl, Br) in greater than 95% radio-chemical purity, suitable for in vivo evaluation as a myocardial imaging agent, is described. Reaction parameters that lead to the formation of the desired products, as well as those that lead to the formation of the major impurities, are delineated. The 99 m Tc species are characterized by HPLC using the known 99Tc analogs as standards. Myocardial images obtained in mongrel dogs with [ 99 m Tc(DMPE) 2X 2] + ( X = Cl, Br) are briefly discussed.
ISSN:0020-708X
DOI:10.1016/0020-708X(83)90007-8