Cerebellar Hypoplasia in Neonatal Rats Caused by Lymphocytic Choriomeningitis Virus

Lymphocytic choriomeningitis virus, strain E-350, when inoculated intracerebrally in rats 1 to 7 days old, produces an acute destructive infection of the cerebellar cortex resulting in permanent cerebellar hypoplasia and ataxia. Several other arenoviruses may produce a similar lesion in neonatal rod...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1971-01, Vol.171 (3967), p.194-196
Main Authors: Monjan, Andrew A., Gilden, Donald H., Cole, Gerald A., Nathanson, Neal
Format: Article
Language:English
Subjects:
Animals
Animals, Newborn
Antibodies
Ataxia - etiology
Blood plasma
Cerebellar Cortex - pathology
Cerebellar Diseases - etiology
Cerebellum
Demyelinating Diseases
Infections
Inoculation
Lesions
Lymphocytic Choriomeningitis - complications
Lymphocytic Choriomeningitis - pathology
Lymphocytic choriomeningitis virus
Lymphocytic choriomeningitis virus - pathogenicity
Necrosis
Rats
Viruses
Viruses, Unclassified - pathogenicity
Von Willebrand diseases
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Summary:Lymphocytic choriomeningitis virus, strain E-350, when inoculated intracerebrally in rats 1 to 7 days old, produces an acute destructive infection of the cerebellar cortex resulting in permanent cerebellar hypoplasia and ataxia. Several other arenoviruses may produce a similar lesion in neonatal rodents.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.171.3967.194