A Theoretical Model for Insulin Secretory Dynamics in a Hybrid Artificial Pancreas

Lack of normal insulin release by the pancreas may contribute to the long-term complications associated with diabetes. In an effort to restore physiological insulin delivery, an artificial hybrid pancreas is being developed for implantation in the circulatory system as an arteriovenous shunt. Glucos...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 1983-01, Vol.413 (1), p.421-423
Main Authors: WEINLESS, NAOMI L., COLTON, CLARK K.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Biotechnology
Fundamental and applied biological sciences. Psychology
glucose
Health. Pharmaceutical industry
Industrial applications and implications. Economical aspects
insulin
Insulin - metabolism
Insulin Infusion Systems
Insulin Secretion
Islets of Langerhans - metabolism
Kinetics
membrane permeability
pancreas
Production of active biomolecules
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Summary:Lack of normal insulin release by the pancreas may contribute to the long-term complications associated with diabetes. In an effort to restore physiological insulin delivery, an artificial hybrid pancreas is being developed for implantation in the circulatory system as an arteriovenous shunt. Glucose diffuses from the tubular lumen across the membrane to the islet cells, which secrete appropriate amounts of insulin that diffuse back into the lumen and into the surrounding shell. The membrane is permeable to insulin and glucose but excludes the larger antibodies and lymphocytes, thus circumventing the problem of immune rejection.
ISSN:0077-8923
1749-6632
DOI:10.1111/j.1749-6632.1983.tb47919.x