Analysis of the action of the neuropeptide-inducing delta-sleep in cats and white rats

Suboccipital administration of the oligopeptide to adult cats and white rats in a dose of 15 and 20 micrograms/kg induces the appearance of electrographic (delta-sleep) and behavioral sleep within 15-25 min. Administration of the oligopeptide induces a substantial increase in the thresholds of the r...

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Bibliographic Details
Published in:Neuroscience and behavioral physiology 1983-11, Vol.13 (6), p.476-481
Main Authors: Karmanova, I G, Maksimuk, V F, Voronov, I B, Bogoslovskii, M M, Demin, N N, Rubinskaya, N L, Al'bertin, S V
Format: Article
Language:English
Subjects:
Animals
Cats
Delta Sleep-Inducing Peptide
Dose-Response Relationship, Drug
Electroencephalography
Female
Male
Oligopeptides - pharmacology
Rats
Sleep - drug effects
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Summary:Suboccipital administration of the oligopeptide to adult cats and white rats in a dose of 15 and 20 micrograms/kg induces the appearance of electrographic (delta-sleep) and behavioral sleep within 15-25 min. Administration of the oligopeptide induces a substantial increase in the thresholds of the response of the EEG to phonostimulation. A substantial lag (50-90 min) in the onset of paradoxical sleep is noted, which is considered by the authors as a manifestation of inhibition, exerted by the neuropeptide on the further development of the sleep mechanisms. On the basis of the data obtained it is concluded that natural sleep and that induced by the neuropeptide are nonequivalent.
ISSN:0097-0549
1573-899X
DOI:10.1007/BF01182693