Adenosine 3′,5′-Monophosphate in Nervous Tissue: Increase Associated with Synaptic Transmission

Brief periods of stimulation of the preganglionic nerve fibers produced a severalfold increase in the content of adenosine 3′,5′-monophosphate in superior cervical sympathetic ganglia, whereas postganglionic stimulation did not. These and other experiments indicated that the increased concentrations...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1971-03, Vol.171 (3976), p.1156-1158
Main Authors: McAfee, Donald A., Schorderet, Michel, Greengard, Paul
Format: Article
Language:English
Subjects:
Adenine Nucleotides - metabolism
Animals
Atropine - pharmacology
Autonomic Fibers, Postganglionic - metabolism
Autonomic Fibers, Preganglionic - physiology
Cyclic AMP - metabolism
Ganglia
Nerve tissue
Nerves
Neurons
Pollen tubes
Seed weight
Superior cervical ganglion
Sympathetic ganglia
Synaptic transmission
Zygotes
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Summary:Brief periods of stimulation of the preganglionic nerve fibers produced a severalfold increase in the content of adenosine 3′,5′-monophosphate in superior cervical sympathetic ganglia, whereas postganglionic stimulation did not. These and other experiments indicated that the increased concentrations of adenosine 3′5′-monophosphate were closely associated with the process of synaptic transmission. This increase occurred primarily in postsynaptic cells.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.171.3976.1156