The effect of isordil and cyclospasmol on vascular spasm induced in the basilar artery of the cat

Vasospasm of the basilar artery of the cat was induced by subarachnoid bleeding and was observed by a transoral approach to the vessel. Intravenous Isordil (2 to 4 mg/kg) given following vasospasm produced vasodilatation with minimal arterial hypotension. Cyclospasmol, administered intravenously aft...

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Bibliographic Details
Published in:Stroke (1970) 1970-09, Vol.1 (5), p.325-329
Main Authors: Mahaley, Jr, M S, Kapp, J
Format: Article
Language:English
Subjects:
Animals
Basilar Artery - anatomy & histology
Basilar Artery - drug effects
Basilar Artery - physiology
Cats
Cyclohexanes - pharmacology
Cyclohexanes - therapeutic use
Furans - pharmacology
Furans - therapeutic use
Ischemic Attack, Transient - drug therapy
Ischemic Attack, Transient - etiology
Isosorbide Dinitrate - pharmacology
Isosorbide Dinitrate - therapeutic use
Mandelic Acids - pharmacology
Mandelic Acids - therapeutic use
Nitrates - pharmacology
Nitrates - therapeutic use
Parasympatholytics - pharmacology
Sorbitol - pharmacology
Sorbitol - therapeutic use
Spasm
Subarachnoid Hemorrhage - drug therapy
Subarachnoid Space - physiology
Vasodilator Agents - pharmacology
Vasomotor System - physiology
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Summary:Vasospasm of the basilar artery of the cat was induced by subarachnoid bleeding and was observed by a transoral approach to the vessel. Intravenous Isordil (2 to 4 mg/kg) given following vasospasm produced vasodilatation with minimal arterial hypotension. Cyclospasmol, administered intravenously after vasospasm or orally prior to vasospasm, was ineffective in relieving or preventing basilar artery spasm.
ISSN:0039-2499
1524-4628
DOI:10.1161/01.STR.1.5.325