IN VITRO ANTIBACTERIAL ACTIVITY OF CEFOPERAZONE

The in vitro antibacterial activities of cefoperazone (CPZ) against clinical isolates including various-lactamase-producing strains were studied and compared with those of cefotiam (CTM).CPZ βhad a broad spectrum against Gram-negative and Gram-positive bacteria. Especially, CPZ showed apparently mor...

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Published in:Japanese journal of antibiotics 1983/12/25, Vol.36(12), pp.3437-3443
Main Authors: WATANABE, YASUO, MINAMI, SHINZABUROU, YOTSUJI, AKIRA, ARAKI, HARUMI, YASUDA, TAKASHI, SAIKAWA, ISAMU
Format: Article
Language:Japanese
Subjects:
Bacteria - drug effects
Bacteria - enzymology
beta-Lactamases - biosynthesis
Cefoperazone - pharmacology
Drug Resistance, Microbial
Enzyme Induction - drug effects
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container_end_page 3443
container_issue 12
container_start_page 3437
container_title Japanese journal of antibiotics
container_volume 36
creator WATANABE, YASUO
MINAMI, SHINZABUROU
YOTSUJI, AKIRA
ARAKI, HARUMI
YASUDA, TAKASHI
SAIKAWA, ISAMU
description The in vitro antibacterial activities of cefoperazone (CPZ) against clinical isolates including various-lactamase-producing strains were studied and compared with those of cefotiam (CTM).CPZ βhad a broad spectrum against Gram-negative and Gram-positive bacteria. Especially, CPZ showed apparently more potent antibacterial activities than CTM against Enterobacter cloacae, Serratia marcescens, and Pseudomonas aeruginosa.However, CPZ was less active than CTM against Staphylococcus aureus and Proteus mirabilis. The stability and affinity of CPZ for various types of β-lactamase were also studied.CPZ was more resistant to hydrolysis by typical cephalosporinase (CSase) and cefuroximase (CXase) than CTM, but was less stable to penicillinase (PCase).CPZ often showed higher affinity to β-lactamases than CTM.The study for the inducer-activity revealed that CPZ hardly induced CSase production in E. cloacae and Proteus vulgaris while CTM highly induced in both strains. CPZ was more active against CSase-producers than CTM, especially against strains which inducibly produced the enzyme.It was speculated that this activity was responsible for the superior stability to CSase and low inducer-activity for CSase production.
doi_str_mv 10.11553/antibiotics1968b.36.3437
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issn 0368-2781
2186-5477
language jpn
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source Alma/SFX Local Collection
subjects Bacteria - drug effects
Bacteria - enzymology
beta-Lactamases - biosynthesis
Cefoperazone - pharmacology
Drug Resistance, Microbial
Enzyme Induction - drug effects
title IN VITRO ANTIBACTERIAL ACTIVITY OF CEFOPERAZONE
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