Restricting Elements in the Immunological Circuitry: the Role of I Region-Controlled Determinants

The I region controls a series of determinants selectively expressed on T cells and are the major elements that restrict the cell interaction to lead to the suppression or augmentation of the immune response. In order to delineate the mechanism of such restrictions, the authors have attempted to stu...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 1983-01, Vol.418 (1), p.189-195
Main Authors: TADA, TOMIO, OKUMURA, KO, MIYATANI, SEIJI, OCHI, ATSUO, NAKAUCHI, HIROMITSU, KARASUYAMA, HAJIME
Format: Article
Language:English
Subjects:
Animals
Antibodies, Monoclonal - immunology
Cell Line
Epitopes
Gene Expression Regulation
Genes, MHC Class II
Histocompatibility Antigens Class II - immunology
Hybridomas - immunology
Immunoglobulin Idiotypes - immunology
Mice
T-Lymphocytes - immunology
T-Lymphocytes, Regulatory - immunology
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Summary:The I region controls a series of determinants selectively expressed on T cells and are the major elements that restrict the cell interaction to lead to the suppression or augmentation of the immune response. In order to delineate the mechanism of such restrictions, the authors have attempted to study the immunochemical properties of I region-controlled (Iat) determinants on T cells. This paper deals with the serological and immunochemical analysis of Iat structures on hybridomas and cell lines, and considers the roles of such polymorphic determinants in the restricted interactions among the members in the immunological circuit.
ISSN:0077-8923
1749-6632
DOI:10.1111/j.1749-6632.1983.tb18066.x