Auto-antibodies to Actin: Recent Findings

Actin is a highly conserved protein changing very little from species to species. This might explain why it is difficult to produce potent antisera and necessary to use denatured actin for immunization. In view of the amount of actin existing in all cells and the release of actin when cells break do...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 1983, Vol.420 (1), p.297-301
Main Authors: FAGRAEUS, A., NORBERG, R., THORSTENSSON, R., UTTER, G., ÖURVELL, C.
Format: Article
Language:English
Subjects:
Actins - immunology
Animals
Antibodies, Monoclonal - immunology
Antibody Specificity
Autoantibodies - immunology
Epitopes
Humans
Mice
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Summary:Actin is a highly conserved protein changing very little from species to species. This might explain why it is difficult to produce potent antisera and necessary to use denatured actin for immunization. In view of the amount of actin existing in all cells and the release of actin when cells break down, tolerance should be expected and it is surprising that auto-antibodies to actin are produced. Virus infections have been discussed as a mechanism for breaking tolerance perhaps by formation of virus-actin complexes.
ISSN:0077-8923
1749-6632
DOI:10.1111/j.1749-6632.1983.tb22215.x