Cysteamine rapidly decreases mitotic cells in random culture of HeLa S-3 cells

Mitotic cells disappeared nearly completely within 60 min after the addition of 30 mM cysteamine in HeLa S-3 cell culture, while the control culture contained mitotic cells with the frequency of 3.4%. Inhibition of mitosis became gradually irreversible when the treatment was extended over 60 min, bu...

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Bibliographic Details
Published in:Journal of radiation research 1983-01, Vol.24 (4), p.285-290
Main Authors: Takagi, Y, Shikita, M
Format: Article
Language:English
Subjects:
Cysteamine - pharmacology
Ethanolamine
Ethanolamines - pharmacology
HeLa Cells - drug effects
Humans
Mitosis - drug effects
Time Factors
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Summary:Mitotic cells disappeared nearly completely within 60 min after the addition of 30 mM cysteamine in HeLa S-3 cell culture, while the control culture contained mitotic cells with the frequency of 3.4%. Inhibition of mitosis became gradually irreversible when the treatment was extended over 60 min, but cytolysis occurred much more slowly. Ethanolamine exhibited a similar but much less significant effect.
ISSN:0449-3060
1349-9157
DOI:10.1269/jrr.24.285