IgA Class Endomysium Antibodies in Dermatitis Herpetiformis and Coeliac Disease

Dermatitis herpetiformis (DH) is a vesicular skin disorder with characteristic histologic features (PMNs, microabscesses in dermal papillae adjacent to the vesicles) and disease-specific immunopathological findings (granular of fibrillar IgA deposits most commonly found in dermal papillae) usually a...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 1983, Vol.420 (1), p.325-334
Main Authors: CHORZELSKI, TADEUSZ P., SULEJ, JADWIGA, TCHORZEWSKA, HANNA, JABLONSKA, STEFANIA, BEUTNER, ERNST H., KUMAR, VIJAY
Format: Article
Language:English
Subjects:
Animals
Basement Membrane - immunology
Celiac Disease - immunology
Dermatitis Herpetiformis - immunology
Esophagus - immunology
Humans
Immunoglobulin A - analysis
Muscle, Smooth - immunology
Muscles - immunology
Pemphigoid, Bullous - immunology
Skin - immunology
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Summary:Dermatitis herpetiformis (DH) is a vesicular skin disorder with characteristic histologic features (PMNs, microabscesses in dermal papillae adjacent to the vesicles) and disease-specific immunopathological findings (granular of fibrillar IgA deposits most commonly found in dermal papillae) usually associated with gluten-sensitive enteropathy. This report sets forth the first findings on IgA class antibody reacting with endomysium IgA-EmA of smooth muscle, particularly of monkey esophagus. The authors have found these IgA-EmA in a significant proportion of patients with DH, coeliac disease, and other gut diseases. Both IgA-EmA and IgG-AGA anti-gliadin antibodies can be detected on monkey esophagus in the same serum sample by the indirect IF test.
ISSN:0077-8923
1749-6632
DOI:10.1111/j.1749-6632.1983.tb22220.x