Optimization of batch fermentation processes. II. Optimum temperature profiles for batch penicillin fermentations

Optimization methods based on the continuous maximum principle and the calculus of variations were used to calculate optimum temperature profiles for batch penicillin fermentations. These methods were first applied to several general models to develop effective techniques for the numerical solution...

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Bibliographic Details
Published in:Biotechnology and bioengineering 1970-11, Vol.12 (6), p.1081-1098
Main Authors: Constantinides, Alkis, Spencer, Jordan L., Gaden Jr, Elmer L.
Format: Article
Language:English
Subjects:
Fermentation
Mathematics
Methods
Models, Biological
Penicillins - metabolism
Temperature
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Summary:Optimization methods based on the continuous maximum principle and the calculus of variations were used to calculate optimum temperature profiles for batch penicillin fermentations. These methods were first applied to several general models to develop effective techniques for the numerical solution of the equations. Subsequently, these methods were applied to two particular models, derived from experimental data, and the optimum temperature profiles were determined. The results indicated that an improvement, in penicillin yield of about 15% was possible if the optimum temperature profiles were followed.
ISSN:0006-3592
1097-0290
DOI:10.1002/bit.260120613