Brain metastases from colon cancer

Between 1977 and 1980 we evaluated 40 patients who developed brain metastases from colon cancer (4% of total patients with colon cancer). The brain metastasis was discovered in only one patient prior to cancer diagnosis; all others had known colon cancer for 2 to 48 months (median 24.5 months) prior...

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Bibliographic Details
Published in:Journal of neuro-oncology 1983, Vol.1 (3), p.203-209
Main Authors: Cascino, T L, Leavengood, J M, Kemeny, N, Posner, J B
Format: Article
Language:English
Subjects:
Adenocarcinoma - diagnosis
Adenocarcinoma - secondary
Adenocarcinoma - therapy
Adult
Aged
Brain - diagnostic imaging
Brain Neoplasms - diagnosis
Brain Neoplasms - secondary
Brain Neoplasms - therapy
Colonic Neoplasms - diagnosis
Colonic Neoplasms - therapy
Female
Humans
Male
Middle Aged
Prognosis
Tomography, X-Ray Computed
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Summary:Between 1977 and 1980 we evaluated 40 patients who developed brain metastases from colon cancer (4% of total patients with colon cancer). The brain metastasis was discovered in only one patient prior to cancer diagnosis; all others had known colon cancer for 2 to 48 months (median 24.5 months) prior to neurologic presentation. The colon tumor was left-sided in 32; 32 had regional lymph node metastases at neurological presentation; 37 patients had extensive systemic metastasis as well as the brain lesion. Median survival from onset of therapy for brain metastasis was 9 weeks in 32 radiation therapy (RT) treated patients (range, 2-57 weeks), 37 weeks in 7 surgically resected patients (2-84 weeks), and 4 weeks (3.5 weeks) in 2 chemotherapy patients. Follow-up demonstrated recurrent tumor (median 4 months). The prognosis for patients with brain metastasis in colon cancer is poor, regardless of therapy.
ISSN:0167-594X
1573-7373
DOI:10.1007/BF00165604