Gene Product of v-fgr onc: Hybrid Protein Containing a Portion of Actin and a Tyrosine-Specific Protein Kinase

The nucleotide sequence of the region of Gardner-Rasheed feline sarcoma virus (GR-FeSV) encoding its primary translation product, p70$^{\text{gag-fgr}}$, has been determined. From the nucleotide sequence, the amino acid sequence of this transforming protein was deduced. Computer analysis indicates t...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1984-01, Vol.223 (4631), p.63-66
Main Authors: Naharro, German, Robbins, Keith C., Reddy, E. Premkumar
Format: Article
Language:English
Subjects:
actin
Actins
Actins - analysis
Amino Acid Sequence
Amino acids
Base Sequence
Biological and medical sciences
Cancer
Cancer research
Cats
Cell research
Computers
Cytological research
feline sarcoma virus
Fundamental and applied biological sciences. Psychology
Gene Products, gag
Generally accepted auditing standards
genes
Genes, Viral
Genes. Genome
Genomes
Helper viruses
Hybridity
Molecular and cellular biology
Molecular biology
Molecular genetics
nucleotide sequence
Nucleotide sequences
Nucleotides
Oncogenes
Oncology, Experimental
Open reading frames
protein kinase
Protein Kinases - analysis
Protein-Tyrosine Kinases
Recombination, Genetic
Retroviridae - genetics
Sarcoma Viruses, Feline - genetics
v-frg gene
Viral Proteins - analysis
Viral Proteins - genetics
Viral research
Virus research
Viruses
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Summary:The nucleotide sequence of the region of Gardner-Rasheed feline sarcoma virus (GR-FeSV) encoding its primary translation product, p70$^{\text{gag-fgr}}$, has been determined. From the nucleotide sequence, the amino acid sequence of this transforming protein was deduced. Computer analysis indicates that a portion of P70$^{\text{gag-fgr}}$ has extensive amino acid sequence homology with actin, a eukaryotic cytoskeletal protein. A second region of P70$^{\text{gag-fgr}}$ is closely related to the tyrosine-specific kinase gene family. Thus, the v-fgr oncogene appears to have arisen as a result of recombinational events involving two distinct cellular genes, one coding for a structural protein and the other for a protein kinase.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.6318314