The establishment and maintenance of pregnancy using in vitro fertilization and embryo donation in a patient with primary ovarian failure

Ovarian steroid replacement therapy in the ovariectomized ewe, given in the correct sequence to mimic endogenous steroid changes in the normal ovulatory cycle, allows the development of embryos transferred fit in utero 1–3 . A similar type of sequential therapy was designed for steroid replacement i...

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Bibliographic Details
Published in:Nature (London) 1984-01, Vol.307 (5947), p.174-175
Main Authors: Lutjen, Peter, Trounson, Alan, Leeton, John, Findlay, Jock, Wood, Carl, Renou, Peter
Format: Article
Language:English
Subjects:
Bioethics
Biological and medical sciences
Birth control
Embryo Transfer
Estradiol - therapeutic use
Ethics
Female
Fertilization in Vitro
Government Regulation
Gynecology. Andrology. Obstetrics
Humanities and Social Sciences
Humans
letter
Medical sciences
multidisciplinary
Oocyte Donation
Ovarian Diseases - drug therapy
Pregnancy
Science
Science (multidisciplinary)
Sterility. Assisted procreation
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Summary:Ovarian steroid replacement therapy in the ovariectomized ewe, given in the correct sequence to mimic endogenous steroid changes in the normal ovulatory cycle, allows the development of embryos transferred fit in utero 1–3 . A similar type of sequential therapy was designed for steroid replacement in women with primary ovarian failure. This produces the histological changes in uterine endometrial morphology and plasma oestradiol and progesterone similar to those observed in the normal ovulatory cycle 4,5 . We now report that in one of these women a donated oocyte 6 , fertilized by her husband's spermatozoa 7 and cultured to the two-cell stage in vitro , was transferred in utero , resulting in a normal pregnancy and the delivery of a healthy child. Oestrogen therapy was withdrawn at 12 weeks and progesterone at 19 weeks gestation. This technique allows the treatment of human infertility due to primary ovarian failure.
ISSN:0028-0836
1476-4687
DOI:10.1038/307174a0