Influence of changes in lipid values induced by cholestyramine and diet on progression of coronary artery disease: Results of the NHLBI Type II Coronary Intervention Study

In a double-blind, placebo-controlled trial, coronary artery disease (CAD) patients treated with cholestyramine evidenced significant decreases in total cholesterol (TC) and low-density lipoprotein cholesterol (LDLC). Increases in their high-density lipoprotein cholesterol (HDLC), and in their HDLC/...

Full description

Saved in:
Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 1984-02, Vol.69 (2), p.325-337
Main Authors: Levy, Robert I, Brensike, John F, Epstein, Stephen E, Kelsey, Sheryl F, Passamani, Eugene R, Richardson, John M, Loh, Irving K, Stone, Neil J, Aldrich, Robert F, Battaglini, James W
Format: Article
Language:English
Subjects:
Adult
Antianginal agents. Coronary vasodilator agents
Biological and medical sciences
cardiovascular diseases
Cardiovascular system
cholesterol
Cholesterol - blood
Cholesterol, HDL
Cholesterol, LDL
Cholestyramine Resin - therapeutic use
clinical trials
Clinical Trials as Topic
Coronary Disease - blood
Coronary Disease - complications
Coronary Disease - diagnosis
diet
disease prevention
Double-Blind Method
drug therapy
Female
high density lipoprotein
Humans
Hypercholesterolemia - blood
Hypercholesterolemia - complications
Hypercholesterolemia - diet therapy
Hypercholesterolemia - drug therapy
lipid metabolism
Lipoproteins, HDL - blood
Lipoproteins, LDL - blood
low density lipoprotein
Male
Medical sciences
Middle Aged
patient care
Pharmacology. Drug treatments
risk factors
Triglycerides - blood
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In a double-blind, placebo-controlled trial, coronary artery disease (CAD) patients treated with cholestyramine evidenced significant decreases in total cholesterol (TC) and low-density lipoprotein cholesterol (LDLC). Increases in their high-density lipoprotein cholesterol (HDLC), and in their HDLC/TC and HDLC/LDLC ratios were found. A significant inverse correlation was found between CAD progression at 5 years and the combination of an HDLC increase and an LDLC decrease. Changes in the HDLC/TC and HDLC/LDLC ratios were found to best predict CAD change. Statistical analyses of the results support the hypothesis that TC or LDLC decreases and HDLC increases can prevent or postpone CAD risk. (wz)
ISSN:0009-7322
1524-4539
DOI:10.1161/01.CIR.69.2.325