Pulmonary metastases in differentiated thyroid carcinoma. Study of 58 cases with implications for the primary tumor treatment

Fifty‐eight cases of pulmonary metastases (PM) from 831 cases of differentiated thyroid carcinoma (DTC) were studied. PM were found in about 10% of follicular and 5% of papillary tumors. 131I uptake was found in 55% of the cases, irrespective of histology. Twenty‐one patients were treated by 131I on...

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Bibliographic Details
Published in:Cancer 1984-02, Vol.53 (4), p.982-992
Main Authors: Massin, Jean‐Pierre, Savoie, Jean‐Claude, Garnier, Henri, Guiraudon, Gérard, Leger, Françoise A., Bacourt, François
Format: Article
Language:English
Subjects:
Adult
Age Factors
Biological and medical sciences
Endocrinopathies
Humans
Iodine Radioisotopes - therapeutic use
Lung Neoplasms - pathology
Lung Neoplasms - secondary
Lymph Node Excision
Malignant tumors
Medical sciences
Middle Aged
Prognosis
Radionuclide Imaging
Retrospective Studies
Thyroid Neoplasms - diagnostic imaging
Thyroid Neoplasms - pathology
Thyroid Neoplasms - therapy
Thyroid. Thyroid axis (diseases)
Thyroidectomy
Thyroxine - therapeutic use
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Summary:Fifty‐eight cases of pulmonary metastases (PM) from 831 cases of differentiated thyroid carcinoma (DTC) were studied. PM were found in about 10% of follicular and 5% of papillary tumors. 131I uptake was found in 55% of the cases, irrespective of histology. Twenty‐one patients were treated by 131I only and 12 were cured. Micronodular metastases, 92% papillary, with 86% positive 131I uptake and 77% 8‐year survival rate, are the most favorable forms. In others the influence of PM size/age, uptake, delay of appearance, presence of cervical or mediastinal lymph nodes is discussed. Occurrence of late PM according to treatment of the primary tumor was 1.3% thyroidectomy + 131I; 3% thyroidectomy; 5% partial thyroidectomy + 131I; 11% partial thyroidectomy only. Thus prevention in DTC of severe PM (28% 8‐year survival rate) can best be achieved by complete thyroidectomy + 131I ablation dose.
ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(19840215)53:4<982::AID-CNCR2820530427>3.0.CO;2-E