Evolution of the genes for the β subunits of human chorionic gonadotropin and luteinizing hormone

Nucleotide sequence comparisons of the single gene for the human luteinizing hormone gene β subunit with two of the seven genes for the human chorionic gonadotropin β subunit suggest that the β human chorionic gonadotropin genes have evolved from an ancestral β luteinizing hormone gene by a series o...

Full description

Saved in:
Bibliographic Details
Published in:Nature (London) 1984-01, Vol.307 (5946), p.37-40
Main Authors: Talmadge, Karen, Vamvakopoulos, Nikos C, Fiddes, John C
Format: Article
Language:English
Subjects:
Base Sequence
Biological and medical sciences
Biological Evolution
Chorionic Gonadotropin - genetics
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation
Genes
Genetics of eukaryotes. Biological and molecular evolution
Humanities and Social Sciences
Humans
Luteinizing Hormone - genetics
Macromolecular Substances
multidisciplinary
Science
Science (multidisciplinary)
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Nucleotide sequence comparisons of the single gene for the human luteinizing hormone gene β subunit with two of the seven genes for the human chorionic gonadotropin β subunit suggest that the β human chorionic gonadotropin genes have evolved from an ancestral β luteinizing hormone gene by a series of selected changes with very little neutral drift. Moreover, the 24 amino acid carboxy-terminal extension of the human chorionic gonadotropin β subunit appears to have arisen by a single base deletion that incorporated the 3′-untranslated region of the ancestral β luteinizing hormone gene into the coding region.
ISSN:0028-0836
1476-4687
DOI:10.1038/307037a0