Fever and biochemical thermogenesis

Serum free fatty acid versus glycerol ratios were decreased in human newborn infants during pyrexia or cold injury, but remained practically unchanged in older infants and children. Decreased ratios in the newborn resulted exclusively from an increase in serum glycerol. In children a parallel increa...

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Bibliographic Details
Published in:Pediatrics (Evanston) 1971-03, Vol.47 (3), p.571-576
Main Authors: Matsaniotis, N, Pastelis, V, Agathopoulos, A, Constantsas, N
Format: Article
Language:English
Subjects:
Adolescent
Age Factors
Body Temperature Regulation
Child
Child, Preschool
Fatty Acids, Nonesterified - blood
Female
Fever - blood
Glycerol - blood
Humans
Hypothermia - blood
Infant
Infant, Newborn
Male
Shivering
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Summary:Serum free fatty acid versus glycerol ratios were decreased in human newborn infants during pyrexia or cold injury, but remained practically unchanged in older infants and children. Decreased ratios in the newborn resulted exclusively from an increase in serum glycerol. In children a parallel increase in both serum glycerol and free fatty acids was observed in pyrexia. The results suggest that in pyrexia both newborn infants and older children behave as if they were cold, mobilizing the mechanisms of nonshivering and shivering thermogenesis respectively to adjust the temperature of their body at a relatively higher reference level.
ISSN:0031-4005
1098-4275
DOI:10.1542/peds.47.3.571