Synthesis and Characterization of Some 3-Nitroso-2-arylimidazo (1,2-α) pyrimidines

While attempting to prepare amides derived from 2-aminopyrimidine and arylglyoxylohydroxamyl chlorides, deeply colored, highly insoluble products were obtaind. Both IR and NMR data proved that the desired amides had not been obtained. This manuscript details the information used to identify the prod...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 1971-01, Vol.60 (1), p.74-76
Main Authors: Larocca, Joseph P., Gibson, C.A., Blackburn Thompson, B.
Format: Article
Language:English
Subjects:
2-α)-pyrimidines
2-α)pyrimidines-synthesis
3-Nitroso-2-arylimidazo
3-Nitroso-2-arylimidazo(1,2-α)pyrimidines—synthesis
Animals
Anti-Bacterial Agents
Anti-Infective Agents - chemical synthesis
Anti-Infective Agents - pharmacology
Anti-Infective Agents - therapeutic use
Antimicrobial activity-3-nitroso-2-arylimidazo
Antimicrobial activity—3-nitroso-2-arylimidazo(1,2-α)-pyrimidines
Antiviral Agents - chemical synthesis
Candida - drug effects
Cryptococcus - drug effects
Escherichia coli - drug effects
Infrared Rays
IR spectrophotometry-structure
Klebsiella Infections - drug therapy
Magnetic Resonance Spectroscopy
Male
Mice
Microbial Sensitivity Tests
NMR spectroscopy-structure
Pyrimidines - chemical synthesis
Pyrimidines - pharmacology
Pyrimidines - therapeutic use
Spectrophotometry
Staphylococcus - drug effects
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Description
Summary:While attempting to prepare amides derived from 2-aminopyrimidine and arylglyoxylohydroxamyl chlorides, deeply colored, highly insoluble products were obtaind. Both IR and NMR data proved that the desired amides had not been obtained. This manuscript details the information used to identify the products as 3-nitroso-2-arylimidazo(1,2-α)pyrimidines.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600600113