3-O-Methyldopa, a New Precursor of Dopamine

3-METHOXY-4-hydroxyphenylalanine (3-O-methyldopa) is a major metabolite of L -3,4-dihydroxyphenylalanine ( L -dopa) in animals and man 1–4 and when labelled it easily penetrates from the blood into other tissues, for example the brain and heart, where it has a biological half life of 12–13 h, which...

Full description

Saved in:
Bibliographic Details
Published in:Nature (London) 1971-04, Vol.230 (5295), p.533-534
Main Authors: BARTHOLINI, G, KURUMA, I, PLETSCHER, A
Format: Article
Language:English
Subjects:
Animals
Brain - metabolism
Brain Chemistry
Carbon Isotopes
Dealkylation
Dihydroxyphenylalanine - urine
Dopamine - analysis
Dopamine - biosynthesis
Dopamine - urine
Female
Humanities and Social Sciences
letter
Male
Methyldopa - metabolism
Methyldopa - urine
multidisciplinary
Norepinephrine - analysis
Normetanephrine - analysis
Pargyline - pharmacology
Phenylacetates - urine
Rats
Science
Science (multidisciplinary)
Tyramine - analysis
Tyramine - urine
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:3-METHOXY-4-hydroxyphenylalanine (3-O-methyldopa) is a major metabolite of L -3,4-dihydroxyphenylalanine ( L -dopa) in animals and man 1–4 and when labelled it easily penetrates from the blood into other tissues, for example the brain and heart, where it has a biological half life of 12–13 h, which is considerably longer than that of L -dopa, which is about 30 min. The bulk of the urinary radioactivity excreted within 24 h consists of homovanillic acid (3-methoxy-4-hydroxyphenyl-acetic acid) and 3-methoxy-4-hydroxyphenyllactic acid 5 .
ISSN:0028-0836
1476-4687
DOI:10.1038/230533a0