Pneumococci insensitive to Penicillin

PNEUMOCOCCI of all capsular types have been regarded as highly sensitive to penicillin 1 since its introduction for the treatment of human infections in 1940. Although penicillin-insensitive mutants can be selected in vitro by repeated subculture in the presence of sub-inhibitory concentrations of p...

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Bibliographic Details
Published in:Nature (London) 1971-04, Vol.230 (5293), p.407-408
Main Authors: HANSMAN, DAVID, GLASGOW, H. N, STURT, JOHN, DEVITT, LORRAINE, DOUGLAS, R. M
Format: Article
Language:English
Subjects:
Ampicillin - pharmacology
Australia
Cephaloridine - pharmacology
Cephalothin - pharmacology
Humanities and Social Sciences
Humans
letter
Methicillin - pharmacology
multidisciplinary
New Guinea
Penicillin G - pharmacology
Penicillin Resistance
Pneumococcal Infections - microbiology
Science
Science (multidisciplinary)
Streptococcus pneumoniae - drug effects
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Summary:PNEUMOCOCCI of all capsular types have been regarded as highly sensitive to penicillin 1 since its introduction for the treatment of human infections in 1940. Although penicillin-insensitive mutants can be selected in vitro by repeated subculture in the presence of sub-inhibitory concentrations of penicillin 2–6 , resistant wild strains were not recognized until 1967, when penicillin-insensitive pneumococci (type 23) were isolated from a patient with hypogammaglobulinaemia and bronchiectasis, who had received much antibiotic therapy, including penicillin 7 . We now report further strains of pneumococci, isolated in Australia and New Guinea, relatively insensitive to both penicillin and cephalosporin antibiotics.
ISSN:0028-0836
1476-4687
DOI:10.1038/230407a0