Phosphorylation Events during Müllerian Duct Regression

Regression of the fetal rat Müllerian duct in vitro was stimulated by sodium fluoride in the absence of Müllerian inhibiting substance. The action of Müllerian inhibiting substance was inhibited by sodium vanadate, adenosine 5$^{\prime}$-triphosphate, and several related nucleotides in the presence...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1984-02, Vol.223 (4636), p.586-589
Main Authors: Hutson, John M., Fallat, Mary E., Kamagata, Shoichiro, Donahoe, Patricia K., Budzik, Gerald P.
Format: Article
Language:English
Subjects:
Animals
Anti-Mullerian Hormone
Biochemistry
Biological and medical sciences
Cations, Divalent
Cell membranes
Dimethyl Sulfoxide - pharmacology
Embryology: invertebrates and vertebrates. Teratology
Embryonic structures
Epidermal Growth Factor - pharmacology
Female
Fluorides
Fundamental and applied biological sciences. Psychology
Glycoproteins
Growth Inhibitors
Hormone research
Human embryo
Insulin
Kinetics
Male
Membrane Proteins - metabolism
Mullerian Ducts - drug effects
Mullerian Ducts - physiology
Nucleotides
Organogenesis. Physiological fonctions
Phosphatases
Phosphorylation
Pregnancy
Rats
Receptors
Sodium
Sodium Fluoride - pharmacology
Testicular Hormones - physiology
Vanadates
Vanadium - pharmacology
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Summary:Regression of the fetal rat Müllerian duct in vitro was stimulated by sodium fluoride in the absence of Müllerian inhibiting substance. The action of Müllerian inhibiting substance was inhibited by sodium vanadate, adenosine 5$^{\prime}$-triphosphate, and several related nucleotides in the presence of manganese ions. Epidermal growth factor specifically inhibited the substance, but only with manganese ions present. Insulin, platelet-derived growth factor, and nerve growth factor had no effect. These results suggest that dephosphorylation of membrane proteins mediates the action of Mullerian inhibiting substance.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.6607531