Phosphorylation Events during Müllerian Duct Regression

Regression of the fetal rat Müllerian duct in vitro was stimulated by sodium fluoride in the absence of Müllerian inhibiting substance. The action of Müllerian inhibiting substance was inhibited by sodium vanadate, adenosine 5$^{\prime}$-triphosphate, and several related nucleotides in the presence...

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Published in:Science (American Association for the Advancement of Science) 1984-02, Vol.223 (4636), p.586-589
Main Authors: Hutson, John M., Fallat, Mary E., Kamagata, Shoichiro, Donahoe, Patricia K., Budzik, Gerald P.
Format: Article
Language:English
Subjects:
Animals
Anti-Mullerian Hormone
Biochemistry
Biological and medical sciences
Cations, Divalent
Cell membranes
Dimethyl Sulfoxide - pharmacology
Embryology: invertebrates and vertebrates. Teratology
Embryonic structures
Epidermal Growth Factor - pharmacology
Female
Fluorides
Fundamental and applied biological sciences. Psychology
Glycoproteins
Growth Inhibitors
Hormone research
Human embryo
Insulin
Kinetics
Male
Membrane Proteins - metabolism
Mullerian Ducts - drug effects
Mullerian Ducts - physiology
Nucleotides
Organogenesis. Physiological fonctions
Phosphatases
Phosphorylation
Pregnancy
Rats
Receptors
Sodium
Sodium Fluoride - pharmacology
Testicular Hormones - physiology
Vanadates
Vanadium - pharmacology
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container_issue 4636
container_start_page 586
container_title Science (American Association for the Advancement of Science)
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creator Hutson, John M.
Fallat, Mary E.
Kamagata, Shoichiro
Donahoe, Patricia K.
Budzik, Gerald P.
description Regression of the fetal rat Müllerian duct in vitro was stimulated by sodium fluoride in the absence of Müllerian inhibiting substance. The action of Müllerian inhibiting substance was inhibited by sodium vanadate, adenosine 5$^{\prime}$-triphosphate, and several related nucleotides in the presence of manganese ions. Epidermal growth factor specifically inhibited the substance, but only with manganese ions present. Insulin, platelet-derived growth factor, and nerve growth factor had no effect. These results suggest that dephosphorylation of membrane proteins mediates the action of Mullerian inhibiting substance.
doi_str_mv 10.1126/science.6607531
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issn 0036-8075
1095-9203
language eng
recordid cdi_proquest_miscellaneous_80952018
source Science Online_科学在线; JSTOR Archival Journals
subjects Animals
Anti-Mullerian Hormone
Biochemistry
Biological and medical sciences
Cations, Divalent
Cell membranes
Dimethyl Sulfoxide - pharmacology
Embryology: invertebrates and vertebrates. Teratology
Embryonic structures
Epidermal Growth Factor - pharmacology
Female
Fluorides
Fundamental and applied biological sciences. Psychology
Glycoproteins
Growth Inhibitors
Hormone research
Human embryo
Insulin
Kinetics
Male
Membrane Proteins - metabolism
Mullerian Ducts - drug effects
Mullerian Ducts - physiology
Nucleotides
Organogenesis. Physiological fonctions
Phosphatases
Phosphorylation
Pregnancy
Rats
Receptors
Sodium
Sodium Fluoride - pharmacology
Testicular Hormones - physiology
Vanadates
Vanadium - pharmacology
title Phosphorylation Events during Müllerian Duct Regression
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