A New Type D Retrovirus Isolated from Macaques with an Immunodeficiency Syndrome

Macaque monkeys with the recently described acquired immunodeficiency syndrome show a marked defect in T-lymphocyte function and die with opportunistic infections and lymphoproliferative abnormalities. In the study described here a new type D retrovirus was isolated from two Macaca cyclopis with thi...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1984-02, Vol.223 (4636), p.602-605
Main Authors: Daniel, Muthiah D., King, Norval W., Letvin, Norman L., Hunt, Ronald D., Sehgal, Prabhat K., Desrosiers, Ronald C.
Format: Article
Language:English
Subjects:
AIDS (Disease)
AIDS research
AIDS/HIV
Animals
B lymphocytes
Biological and medical sciences
Burkitt Lymphoma
Cell culture techniques
Cell Line
Cell lines
Diseases
DNA
Hepatocytes
Humans
Immunodeficiencies. Immunoglobulinopathies
Immunologic Deficiency Syndromes - microbiology
Immunologic diseases
Immunopathology
Laboratory primates
Lymphocytes
Macaca
Macaca cyclopis
Macaques
Medical sciences
Nucleic Acid Hybridization
Observations
Physiological immunosuppression
Primates as laboratory animals
Retroviridae
Retroviridae - genetics
Retroviridae - immunology
Retroviridae - isolation & purification
T lymphocytes
Viral research
Virus research
Viruses
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Description
Summary:Macaque monkeys with the recently described acquired immunodeficiency syndrome show a marked defect in T-lymphocyte function and die with opportunistic infections and lymphoproliferative abnormalities. In the study described here a new type D retrovirus was isolated from two Macaca cyclopis with this syndrome. This virus is related to, but distinct from, Mason-Pfizer monkey virus, a type D retrovirus previously isolated from a mammary tumor of a rhesus monkey (Macaca mulatta).
ISSN:0036-8075
1095-9203
DOI:10.1126/science.6695172