The Effect of Neonatal Hyperbilirubinemia on the Measurement of Plasma Creatinine

Bilirubin interferes with the measurement of plasma creatinine by the kinetic colorimetric Jaffe reaction, the method currently used by many hospital laboratories. The purpose of the present study was to evaluate the influence of unconjugated bilirubin on the measurement of plasma creatinine by the...

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Published in:Clinical pediatrics 1984-03, Vol.23 (3), p.154-156
Main Authors: Feld, Leonard G., Langford, Daniel J., Schwartz, George J.
Format: Article
Language:English
Subjects:
Bilirubin - blood
Biological and medical sciences
Colorimetry - methods
Creatinine - blood
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Infant, Newborn
Jaundice, Neonatal - blood
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Medical sciences
Other diseases. Semiology
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container_title Clinical pediatrics
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creator Feld, Leonard G.
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description Bilirubin interferes with the measurement of plasma creatinine by the kinetic colorimetric Jaffe reaction, the method currently used by many hospital laboratories. The purpose of the present study was to evaluate the influence of unconjugated bilirubin on the measurement of plasma creatinine by the AutoAnalyzer Jaffe end point method. This colorimetric method is slower but more precise and accurate in the range of 0.25 to 0.5 mg/dl. We found that bilirubin from jaundiced neonates and from stock solutions did not affect the determination of creatinine chro mogen in plasma or in saline, even at concentrations as high as 25 mg/dl. We conclude that the use of the Jaffe end point AutoAnalyzer method with a blank run before each sample will provide an accurate measurement of creatinine in the plasma of the neonate with unconjugated hyper bilirubinemia.
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subjects Bilirubin - blood
Biological and medical sciences
Colorimetry - methods
Creatinine - blood
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Infant, Newborn
Jaundice, Neonatal - blood
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Medical sciences
Other diseases. Semiology
title The Effect of Neonatal Hyperbilirubinemia on the Measurement of Plasma Creatinine
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