Cholecystectomy as a risk factor for gastric cancer: Cohort study

Extract: Epidemiological findings suggest that gallstone disease and some frequent human cancers share common risk factors. In the present historical prospective cohort study, comprising 16,773 patients who had undergone cholecystectomy 12-15 years previously, the risk of developing gastric cancer w...

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Bibliographic Details
Published in:Digestive diseases and sciences 1984-02, Vol.29 (2), p.116-120
Main Authors: Gustavsson, S, Adami, H.O, Meirik, O, Nyren, O, Krusemo, U.-B
Format: Article
Language:English
Subjects:
Adult
Age Factors
Aged
Biological and medical sciences
carcinoma
cholecystectomy
Cholecystectomy - adverse effects
cholelithiasis
digestive system diseases
disease diagnosis
Duodenogastric Reflux - etiology
epidemiology
Esophageal Neoplasms - etiology
Evaluation Studies as Topic
Female
Gallbladder Diseases - surgery
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Male
Medical sciences
Middle Aged
neoplasms
Other diseases. Semiology
Postoperative Complications
prediction
Prospective Studies
Registries
Risk
Stomach Neoplasms - etiology
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Sweden
Time Factors
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Summary:Extract: Epidemiological findings suggest that gallstone disease and some frequent human cancers share common risk factors. In the present historical prospective cohort study, comprising 16,773 patients who had undergone cholecystectomy 12-15 years previously, the risk of developing gastric cancer was investigated. The total number of observed gastric cancers (89) was very close to the expected number (88), giving a relative risk (RR) of 1.01. A significantly increased risk of developing gastric cancer was found during the first year after cholecystectomy, and this increase was judged to be due to cancers that were present but overlooked at the time of cholecystectomy. Subgrouping according to age at surgery revealed a tendency towards a lower risk in patients operated on before the age of 70 years. It is concluded that our data do not support the hypothesis that there are common risk factors for gallstones and cancer, and cholecystectomy does not seem to be associated with an increased risk of gastric cancer within 15 years after this operation. (author)
ISSN:0163-2116
1573-2568
DOI:10.1007/BF01317051