Azulene Analogs of Pharmacologic Agents I: Amides

The paper describes the synthesis of 15 azulene analogs of the benzenoid pharmacologic agent procainamide as part of a study of the pharmacodynamic effects of nonbenzenoid aromatic compounds. Three distinct series of compounds were prepared: azulene-1-carboxamides, 1-(3-nitroazulene)-carboxamides, a...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 1971-02, Vol.60 (2), p.184-189
Main Authors: Doukas, Peter H., Speaker, Tully J.
Format: Article
Language:English
Subjects:
Amides - chemical synthesis
Azulene analogs
Azulene analogs, procainamide—synthesis
Chromatography
Column chromatography-separation
Infrared Rays
IR spectrophotometry-structure
Procainamide
Procainamide azulene analogs-synthesis
procainamide-synthesis
Spectrophotometry
Ultraviolet Rays
UV spectrophotometry-structure
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Description
Summary:The paper describes the synthesis of 15 azulene analogs of the benzenoid pharmacologic agent procainamide as part of a study of the pharmacodynamic effects of nonbenzenoid aromatic compounds. Three distinct series of compounds were prepared: azulene-1-carboxamides, 1-(3-nitroazulene)-carboxamides, and 1-(3-acetamidoazulene)-carboxamides. The preparation of 3-nitroazuloic acid, a new azulene intermediate, is also described.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600600204