The Relationship of Oxygen Uptake to Superoxide Dismutase and Catalase Activity in Human Skeletal Muscle

Abstract A considerable amount of evidence now makes it clear that aerobic tissues require an elaborate enzyme system to remove the harmful reaction products of oxygen reduction. A portion of this protective system has been studied in human muscle and rat tissues. The V̇O 2 max as well as the supero...

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Bibliographic Details
Published in:International journal of sports medicine 1984-02, Vol.5 (1), p.11-14
Main Authors: Jenkins, R. R., Friedland, R., Howald, H.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Animals
Applied physiology
Biological and medical sciences
Catalase - metabolism
Cross-Sectional Studies
Human physiology applied to population studies and life conditions. Human ecophysiology
Humans
Liver - metabolism
Lung - metabolism
Male
Medical sciences
Muscles - metabolism
Myocardium - metabolism
Originals
Oxygen Consumption
Physical Exertion
Rats
Rats, Inbred Strains
Space life sciences
Superoxide Dismutase - metabolism
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Summary:Abstract A considerable amount of evidence now makes it clear that aerobic tissues require an elaborate enzyme system to remove the harmful reaction products of oxygen reduction. A portion of this protective system has been studied in human muscle and rat tissues. The V̇O 2 max as well as the superoxide dismutase and catalase activity of vastus lateralis muscle of 12 healthy, male subjects was measured. The subjects with a high aerobic capacity (V̇O 2 max > 60 ml·kg -1 ·min -1 ) had significantly greater levels of both superoxide dismutase and catalase. There was also a linear relationship between both superoxide dismutase and catalase and V̇O 2 max. The tissue oxygen consumption, and enzyme activity of the liver, heart, lung, and gastrocnemius from 24 rats was also studied. There was a significant rank order correlation between tissue V̇O 2 and tissue enzyme activity of both superoxide dismutase and catalase.
ISSN:0172-4622
1439-3964
DOI:10.1055/s-2008-1025872