Hypercalcemia in chronic granulocytic leukemia

Two patients with the accelerated phase of chronic granulocytic leukemia (CGL) complicated by hypercalcemia are described. Both patients had extensive leukemia, and it is likely that hypercalcemia was secondary to bone destruction. However, one of these patients also had acute renal failure and neit...

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Bibliographic Details
Published in:Cancer 1971-04, Vol.27 (4), p.872-880
Main Authors: Haskell, Charles M., Devita, Vincent T., Canellos, George P.
Format: Article
Language:English
Subjects:
Acute Kidney Injury - complications
Adrenal Cortex Hormones - therapeutic use
Adult
Antineoplastic Agents - therapeutic use
Blood Urea Nitrogen
Bone Diseases - complications
Calcium - blood
Chronic Disease
Creatinine - blood
Diagnosis, Differential
Female
Humans
Hypercalcemia - complications
Hypercalcemia - diagnosis
Hypercalcemia - diagnostic imaging
Hypercalcemia - drug therapy
Hypercalcemia - etiology
Hypercalcemia - pathology
Hypercalcemia - physiopathology
Leukemia, Myeloid - complications
Leukemia, Myeloid - diagnosis
Leukemia, Myeloid - diagnostic imaging
Leukemia, Myeloid - drug therapy
Leukemia, Myeloid - pathology
Leukemia, Myeloid - physiopathology
Male
Middle Aged
Phosphates - blood
Prognosis
Radiography
Skull - diagnostic imaging
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Description
Summary:Two patients with the accelerated phase of chronic granulocytic leukemia (CGL) complicated by hypercalcemia are described. Both patients had extensive leukemia, and it is likely that hypercalcemia was secondary to bone destruction. However, one of these patients also had acute renal failure and neither patient had measurements of plasma parathormone, so other mechanisms of hypercalcemia cannot be excluded entirely. On the basis of these patients and a review of the literature, we conclude that hypercalcemia rarely complicates CGL, that its presence appears to signify a grave prognosis, and that treatment should include antileukemic therapy as well as other measures known to help control hypercalcemia in malignant disorders.
ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(197104)27:4<872::AID-CNCR2820270417>3.0.CO;2-D