Loading…

Exchangeable sodium and blood volume in normotensive and hypertensive humans on high and low sodium intake

Eight normotensive and eight essential hypertensive humans were studied when on high and low sodium intake. Total 24-hr exchangeable body sodium, blood volume, serum sodium concentration, hematocrit, body weight, and mean arterial pressures, when the subjects were supine and upright, were measured....

Full description

Saved in:
Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 1971-04, Vol.43 (4), p.508-519
Main Authors: Brown, Jr, W J, Brown, F K, Krishan, I
Format: Article
Language:English
Subjects:
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c373t-3bb9c759fe13a5f182a4a7e0dd28336ae7588599a5a4499a0cd62c209192eb793
cites
container_end_page 519
container_issue 4
container_start_page 508
container_title Circulation (New York, N.Y.)
container_volume 43
creator Brown, Jr, W J
Brown, F K
Krishan, I
description Eight normotensive and eight essential hypertensive humans were studied when on high and low sodium intake. Total 24-hr exchangeable body sodium, blood volume, serum sodium concentration, hematocrit, body weight, and mean arterial pressures, when the subjects were supine and upright, were measured. Plasma and nonplasma sodium fractions, nonplasma weight, and plasma, cell, and whole blood volumes, as referred to body weight and height, were calculated. Changes in these parameters with diet were also calculated. Specific differences between normotensives and hypertensives were found, in absolute values and with changes with diet. The hypertensives fell into two groups with regard to exchangeable sodium: in four the values varied with diet and in the other four, the values remained low regardless of diet. The "variable-sodium" patients had high upright arterial pressures when on high salt intake and normal upright pressures when on low salt intake. "Low-sodium" patients had high arterial pressures on both diets. Changes in upright pressures of hypertensives correlated significantly (r = 0.73) with changes in nonplasma exchangeable sodium.
doi_str_mv 10.1161/01.CIR.43.4.508
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_80963723</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>80963723</sourcerecordid><originalsourceid>FETCH-LOGICAL-c373t-3bb9c759fe13a5f182a4a7e0dd28336ae7588599a5a4499a0cd62c209192eb793</originalsourceid><addsrcrecordid>eNo9kD1PwzAQhi0EKqUwMyF5YkvqzzgeUVWgUiUkBLPlJJcmJbFL3BT67wmlZXp1d8-9w4PQLSUxpQmdEhrPFq-x4LGIJUnP0JhKJiIhuT5HY0KIjhRn7BJdhbAexoQrOUIjoZlWio3Rev6dV9atwGYN4OCLum-xdQXOGu8LvPNN3wKuHXa-a_0WXKh3cACq_Qa606LqW-sC9g5X9ao63Bv_deqr3dZ-wDW6KG0T4OaYE_T-OH-bPUfLl6fF7GEZ5VzxbcSzTOdK6hIot7KkKbPCKiBFwVLOEwtKpqnU2korxBAkLxKWM6KpZpApzSfo_q930_nPHsLWtHXIoWmsA98HkxI9WGB8AKd_YN75EDoozaarW9vtDSXm164h1Ax2jeBGmMHu8HF3rO6zFop__qiT_wAaPnab</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>80963723</pqid></control><display><type>article</type><title>Exchangeable sodium and blood volume in normotensive and hypertensive humans on high and low sodium intake</title><source>EZB Electronic Journals Library</source><creator>Brown, Jr, W J ; Brown, F K ; Krishan, I</creator><creatorcontrib>Brown, Jr, W J ; Brown, F K ; Krishan, I</creatorcontrib><description>Eight normotensive and eight essential hypertensive humans were studied when on high and low sodium intake. Total 24-hr exchangeable body sodium, blood volume, serum sodium concentration, hematocrit, body weight, and mean arterial pressures, when the subjects were supine and upright, were measured. Plasma and nonplasma sodium fractions, nonplasma weight, and plasma, cell, and whole blood volumes, as referred to body weight and height, were calculated. Changes in these parameters with diet were also calculated. Specific differences between normotensives and hypertensives were found, in absolute values and with changes with diet. The hypertensives fell into two groups with regard to exchangeable sodium: in four the values varied with diet and in the other four, the values remained low regardless of diet. The "variable-sodium" patients had high upright arterial pressures when on high salt intake and normal upright pressures when on low salt intake. "Low-sodium" patients had high arterial pressures on both diets. Changes in upright pressures of hypertensives correlated significantly (r = 0.73) with changes in nonplasma exchangeable sodium.</description><identifier>ISSN: 0009-7322</identifier><identifier>EISSN: 1524-4539</identifier><identifier>DOI: 10.1161/01.CIR.43.4.508</identifier><identifier>PMID: 4929772</identifier><language>eng</language><publisher>United States</publisher><subject>Adult ; Blood Pressure ; Blood Volume ; Body Height ; Body Weight ; Diet, Sodium-Restricted ; Extracellular Space - analysis ; Female ; Hematocrit ; Humans ; Hypertension - metabolism ; Hypertension - physiopathology ; Hypertension - therapy ; Male ; Middle Aged ; Posture ; Radioisotope Dilution Technique ; Sodium - analysis ; Sodium - metabolism ; Sodium Isotopes</subject><ispartof>Circulation (New York, N.Y.), 1971-04, Vol.43 (4), p.508-519</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c373t-3bb9c759fe13a5f182a4a7e0dd28336ae7588599a5a4499a0cd62c209192eb793</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4929772$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Brown, Jr, W J</creatorcontrib><creatorcontrib>Brown, F K</creatorcontrib><creatorcontrib>Krishan, I</creatorcontrib><title>Exchangeable sodium and blood volume in normotensive and hypertensive humans on high and low sodium intake</title><title>Circulation (New York, N.Y.)</title><addtitle>Circulation</addtitle><description>Eight normotensive and eight essential hypertensive humans were studied when on high and low sodium intake. Total 24-hr exchangeable body sodium, blood volume, serum sodium concentration, hematocrit, body weight, and mean arterial pressures, when the subjects were supine and upright, were measured. Plasma and nonplasma sodium fractions, nonplasma weight, and plasma, cell, and whole blood volumes, as referred to body weight and height, were calculated. Changes in these parameters with diet were also calculated. Specific differences between normotensives and hypertensives were found, in absolute values and with changes with diet. The hypertensives fell into two groups with regard to exchangeable sodium: in four the values varied with diet and in the other four, the values remained low regardless of diet. The "variable-sodium" patients had high upright arterial pressures when on high salt intake and normal upright pressures when on low salt intake. "Low-sodium" patients had high arterial pressures on both diets. Changes in upright pressures of hypertensives correlated significantly (r = 0.73) with changes in nonplasma exchangeable sodium.</description><subject>Adult</subject><subject>Blood Pressure</subject><subject>Blood Volume</subject><subject>Body Height</subject><subject>Body Weight</subject><subject>Diet, Sodium-Restricted</subject><subject>Extracellular Space - analysis</subject><subject>Female</subject><subject>Hematocrit</subject><subject>Humans</subject><subject>Hypertension - metabolism</subject><subject>Hypertension - physiopathology</subject><subject>Hypertension - therapy</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Posture</subject><subject>Radioisotope Dilution Technique</subject><subject>Sodium - analysis</subject><subject>Sodium - metabolism</subject><subject>Sodium Isotopes</subject><issn>0009-7322</issn><issn>1524-4539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1971</creationdate><recordtype>article</recordtype><recordid>eNo9kD1PwzAQhi0EKqUwMyF5YkvqzzgeUVWgUiUkBLPlJJcmJbFL3BT67wmlZXp1d8-9w4PQLSUxpQmdEhrPFq-x4LGIJUnP0JhKJiIhuT5HY0KIjhRn7BJdhbAexoQrOUIjoZlWio3Rev6dV9atwGYN4OCLum-xdQXOGu8LvPNN3wKuHXa-a_0WXKh3cACq_Qa606LqW-sC9g5X9ao63Bv_deqr3dZ-wDW6KG0T4OaYE_T-OH-bPUfLl6fF7GEZ5VzxbcSzTOdK6hIot7KkKbPCKiBFwVLOEwtKpqnU2korxBAkLxKWM6KpZpApzSfo_q930_nPHsLWtHXIoWmsA98HkxI9WGB8AKd_YN75EDoozaarW9vtDSXm164h1Ax2jeBGmMHu8HF3rO6zFop__qiT_wAaPnab</recordid><startdate>197104</startdate><enddate>197104</enddate><creator>Brown, Jr, W J</creator><creator>Brown, F K</creator><creator>Krishan, I</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197104</creationdate><title>Exchangeable sodium and blood volume in normotensive and hypertensive humans on high and low sodium intake</title><author>Brown, Jr, W J ; Brown, F K ; Krishan, I</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c373t-3bb9c759fe13a5f182a4a7e0dd28336ae7588599a5a4499a0cd62c209192eb793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1971</creationdate><topic>Adult</topic><topic>Blood Pressure</topic><topic>Blood Volume</topic><topic>Body Height</topic><topic>Body Weight</topic><topic>Diet, Sodium-Restricted</topic><topic>Extracellular Space - analysis</topic><topic>Female</topic><topic>Hematocrit</topic><topic>Humans</topic><topic>Hypertension - metabolism</topic><topic>Hypertension - physiopathology</topic><topic>Hypertension - therapy</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Posture</topic><topic>Radioisotope Dilution Technique</topic><topic>Sodium - analysis</topic><topic>Sodium - metabolism</topic><topic>Sodium Isotopes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Brown, Jr, W J</creatorcontrib><creatorcontrib>Brown, F K</creatorcontrib><creatorcontrib>Krishan, I</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brown, Jr, W J</au><au>Brown, F K</au><au>Krishan, I</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Exchangeable sodium and blood volume in normotensive and hypertensive humans on high and low sodium intake</atitle><jtitle>Circulation (New York, N.Y.)</jtitle><addtitle>Circulation</addtitle><date>1971-04</date><risdate>1971</risdate><volume>43</volume><issue>4</issue><spage>508</spage><epage>519</epage><pages>508-519</pages><issn>0009-7322</issn><eissn>1524-4539</eissn><abstract>Eight normotensive and eight essential hypertensive humans were studied when on high and low sodium intake. Total 24-hr exchangeable body sodium, blood volume, serum sodium concentration, hematocrit, body weight, and mean arterial pressures, when the subjects were supine and upright, were measured. Plasma and nonplasma sodium fractions, nonplasma weight, and plasma, cell, and whole blood volumes, as referred to body weight and height, were calculated. Changes in these parameters with diet were also calculated. Specific differences between normotensives and hypertensives were found, in absolute values and with changes with diet. The hypertensives fell into two groups with regard to exchangeable sodium: in four the values varied with diet and in the other four, the values remained low regardless of diet. The "variable-sodium" patients had high upright arterial pressures when on high salt intake and normal upright pressures when on low salt intake. "Low-sodium" patients had high arterial pressures on both diets. Changes in upright pressures of hypertensives correlated significantly (r = 0.73) with changes in nonplasma exchangeable sodium.</abstract><cop>United States</cop><pmid>4929772</pmid><doi>10.1161/01.CIR.43.4.508</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0009-7322
ispartof Circulation (New York, N.Y.), 1971-04, Vol.43 (4), p.508-519
issn 0009-7322
1524-4539
language eng
recordid cdi_proquest_miscellaneous_80963723
source EZB Electronic Journals Library
subjects Adult
Blood Pressure
Blood Volume
Body Height
Body Weight
Diet, Sodium-Restricted
Extracellular Space - analysis
Female
Hematocrit
Humans
Hypertension - metabolism
Hypertension - physiopathology
Hypertension - therapy
Male
Middle Aged
Posture
Radioisotope Dilution Technique
Sodium - analysis
Sodium - metabolism
Sodium Isotopes
title Exchangeable sodium and blood volume in normotensive and hypertensive humans on high and low sodium intake
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-21T22%3A44%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Exchangeable%20sodium%20and%20blood%20volume%20in%20normotensive%20and%20hypertensive%20humans%20on%20high%20and%20low%20sodium%20intake&rft.jtitle=Circulation%20(New%20York,%20N.Y.)&rft.au=Brown,%20Jr,%20W%20J&rft.date=1971-04&rft.volume=43&rft.issue=4&rft.spage=508&rft.epage=519&rft.pages=508-519&rft.issn=0009-7322&rft.eissn=1524-4539&rft_id=info:doi/10.1161/01.CIR.43.4.508&rft_dat=%3Cproquest_cross%3E80963723%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c373t-3bb9c759fe13a5f182a4a7e0dd28336ae7588599a5a4499a0cd62c209192eb793%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=80963723&rft_id=info:pmid/4929772&rfr_iscdi=true