CARDIOVASCULAR EFFECTS OF PANCURONIUM IN MAN

We have investigated the effects of pancuronium bromide (0.07 mg/kg body weight) on heart rate, mean arterial blood pressure, cardiac output and calculated total peripheral resistance in ten artificially ventilated patients, anaesthetized with 60 per cent nitrous oxide in oxygen plus phenoperidine (...

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Bibliographic Details
Published in:British journal of anaesthesia : BJA 1971-04, Vol.43 (4), p.335-338
Main Authors: KELMAN, G.R., KENNEDY, B.R.
Format: Article
Language:English
Subjects:
Adult
Aged
Androstanes - pharmacology
Anesthesia
Arteries
Blood Pressure - drug effects
Carbon Dioxide - metabolism
Cardiac Output - drug effects
Cardiovascular System - drug effects
Female
Ganglionic Blockers
Heart Rate - drug effects
Humans
Male
Middle Aged
Neuromuscular Nondepolarizing Agents - pharmacology
Nitrous Oxide
Oxygen
Piperidines - pharmacology
Vascular Resistance - drug effects
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Summary:We have investigated the effects of pancuronium bromide (0.07 mg/kg body weight) on heart rate, mean arterial blood pressure, cardiac output and calculated total peripheral resistance in ten artificially ventilated patients, anaesthetized with 60 per cent nitrous oxide in oxygen plus phenoperidine (1 mg/15 kg body weight). End-tidal Pco2 was maintained constant at 30±2 mm Hg. There was a marked and statistically significant increase of heart rate of about 25 per cent, accompanied by lesser, but still statistically significant, incerases of cardiac output and mean arterial blood pressure. Total peripheral resistance was unchanged, suggesting that pancuronium has little ganglion-blocking activity.
ISSN:0007-0912
1471-6771
DOI:10.1093/bja/43.4.335