N-[[5-(Trifluoromethyl)-6-methoxy-1-naphthalenyl]thioxomethyl]-N-methylglycine (Tolrestat), a potent, orally active aldose reductase inhibitor

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Bibliographic Details
Published in:Journal of medicinal chemistry 1984-03, Vol.27 (3), p.255-256
Main Authors: Sestanj, Kazimir, Bellini, Francesco, Fung, Steven, Abraham, Nedumparambil, Treasurywala, Adi, Humber, Leslie, Simard-Dequesne, Nicole, Dvornik, Dushan
Format: Article
Language:English
Subjects:
Aldehyde Reductase - antagonists & inhibitors
Animals
Biological and medical sciences
Cattle
Chemistry
Condensed benzenic and aromatic compounds
Diabetes Mellitus, Experimental - enzymology
Exact sciences and technology
Galactitol - metabolism
General and cellular metabolism. Vitamins
Isoquinolines - pharmacology
Lens, Crystalline - enzymology
Medical sciences
Naphthalenes - pharmacology
Organic chemistry
Pharmacology. Drug treatments
Preparations and properties
Rats
Sorbitol - blood
Sugar Alcohol Dehydrogenases - antagonists & inhibitors
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Description
Summary:
ISSN:0022-2623
1520-4804
DOI:10.1021/jm00369a003