Induction of altered chromatin structures by simian virus 40 enhancer and promoter elements

Two simian virus 40 transcriptional promoter elements, the 72-base pair (bp) repeat and the 21-bp repeat region, induce chromatin structures of increased DNase I sensitivity when transposed elsewhere in the viral genome. The induction of a sufficiently long stretch of DNase I-sensitive chromatin lea...

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Bibliographic Details
Published in:Nature (London) 1984-02, Vol.307 (5953), p.708-714
Main Authors: Jongstra, Jan, Reudelhuber, Tim L, Oudet, Pierre, Benoist, Christophe, Chae, Chi-Bom, Jeltsch, Jean-Marc, Mathis, Diane J, Chambon, Pierre
Format: Article
Language:English
Subjects:
Biological and medical sciences
Chromatin - ultrastructure
Chromatin. Chromosome
Deoxyribonucleases
DNA Replication
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation
Genes, Regulator
Humanities and Social Sciences
Molecular and cellular biology
Molecular genetics
multidisciplinary
Nucleosomes - ultrastructure
Operon
Repetitive Sequences, Nucleic Acid
Science
Science (multidisciplinary)
Simian virus 40 - genetics
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Summary:Two simian virus 40 transcriptional promoter elements, the 72-base pair (bp) repeat and the 21-bp repeat region, induce chromatin structures of increased DNase I sensitivity when transposed elsewhere in the viral genome. The induction of a sufficiently long stretch of DNase I-sensitive chromatin leads to the appearance of a visible nucleosome-free region.
ISSN:0028-0836
1476-4687
DOI:10.1038/307708a0