Biologic Properties of Three Newly Established Human Esophageal Carcinoma Cell Lines

Three epithelial cell lines, CE-48T/VGH, CE-69T/-VGH, and CE-81T/VGH, were established from human squamous cell carcinoma of the esophagus. The cells were polygonal with a high nucleus-to-cytoplasm ratio. Many cells were multinucleate. Electron microscopy revealed the presence of tonofilaments and d...

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Bibliographic Details
Published in:JNCI : Journal of the National Cancer Institute 1984-03, Vol.72 (3), p.577-583
Main Authors: Hu, Cheng-po, Hsieh, Hsian-guey, Chien, Kwang-yu, Wang, Pei-yen, Wang, Ching-i, Chen, Chih-yi, Lo, Szecheng J., Wuu, Kuang-dong, Chang, Chungming
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Carcinoembryonic Antigen - analysis
Carcinoma, Squamous Cell - physiopathology
Carcinoma, Squamous Cell - ultrastructure
Cell Line
Esophageal Neoplasms - physiopathology
Esophageal Neoplasms - ultrastructure
Esophagus
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Kinetics
Male
Medical sciences
Mice
Mice, Nude
Microscopy, Electron
Middle Aged
Neoplasm Transplantation
Transplantation, Heterologous
Tumors
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Summary:Three epithelial cell lines, CE-48T/VGH, CE-69T/-VGH, and CE-81T/VGH, were established from human squamous cell carcinoma of the esophagus. The cells were polygonal with a high nucleus-to-cytoplasm ratio. Many cells were multinucleate. Electron microscopy revealed the presence of tonofilaments and desmosomes. Chromosome analysis showed that these 3 cell lines were heteroploids of human origin. When transplanted into BALB/c (nu/nu) mice, CE-69T/VGH and CE-81T/VGH produced tumors, the histology of which proved to be carcinomas. All 3 cell lines secreted carcinoembryonic antigen. However, the secretion patterns were different. These 3 cell lines may provide useful models for the study of human esophageal cancer.
ISSN:0027-8874
1460-2105
DOI:10.1093/jnci/72.3.577