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Serum fluoride levels in morbidly obese patients: enflurane compared with isoflurane anaesthesia

Summary Obese patients are known to metabolise anaesthetic agents more than patients of normal weight. The extent of this was investigated by the measurement of serum fluoride concentrations in 10 morbidly obese patients undergoing gastroplasty. Five were allocated to receive enflurane and five to r...

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Bibliographic Details
Published in:Anaesthesia 1987-07, Vol.42 (7), p.685-689
Main Authors: STRUBE, P. J., HULANDS, G. H., HALSEY, M. J.
Format: Article
Language:English
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Summary:Summary Obese patients are known to metabolise anaesthetic agents more than patients of normal weight. The extent of this was investigated by the measurement of serum fluoride concentrations in 10 morbidly obese patients undergoing gastroplasty. Five were allocated to receive enflurane and five to receive isoflurane supplemented anaesthesia. The mean peak serum fluoride concentrations after enflurane anaesthesia were greater (22.7 μmol/litre, SE 2.9) than after isoflurane anaesthesia (6.5 μmol/ litre. SE 0.6). The mechanisms and implications of this finding are discussed.
ISSN:0003-2409
1365-2044
DOI:10.1111/j.1365-2044.1987.tb05311.x