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Does the DNA methylase Eco dam pair nucleotide sequences to form site-specific duplexes?

The Eco dam methylase is active on denatured DNA and single-stranded synthetic oligonucleotides containing GATC sites. The results suggest that on interaction with single-stranded oligonucleotides the Eco dam methylase is able to form a duplex structure within the GATC site, and that this duplex sit...

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Bibliographic Details
Published in:FEBS letters 1984-03, Vol.168 (1), p.166-168
Main Authors: Buryanov, Ya.I., Zinoviev, V.V., Vienozhinskis, M.T., Malygin, E.G., Nesterenko, V.F., Popov, S.G., Gorbunov, Yu.A.
Format: Article
Language:English
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Summary:The Eco dam methylase is active on denatured DNA and single-stranded synthetic oligonucleotides containing GATC sites. The results suggest that on interaction with single-stranded oligonucleotides the Eco dam methylase is able to form a duplex structure within the GATC site, and that this duplex site is a substrate for enzyme.
ISSN:0014-5793
1873-3468
DOI:10.1016/0014-5793(84)80228-8