Characterization of DNA sequences through which cadmium and glucocorticoid hormones induce human metallothionein-IIA gene

Deletion experiments have defined two stretches of DNA (genetic elements), lying close to the promoter for a human gene for metallothionein, that separately mediate the induction of the gene by heavy metal ions, particularly cadmium, and by glucocorticoid hormones. The element responsible for induct...

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Bibliographic Details
Published in:Nature (London) 1984-04, Vol.308 (5959), p.513-519
Main Authors: Karin, Michael, Haslinger, Alois, Holtgreve, Heidi, Richards, Robert I., Krauter, Paul, Westphal, Hannes M., Beato, Miguel
Format: Article
Language:English
Subjects:
Base Sequence
Biological and medical sciences
Cadmium - pharmacology
Chromosome Deletion
Cloning, Molecular
Dexamethasone - pharmacology
DNA Restriction Enzymes
Fundamental and applied biological sciences. Psychology
Gene expression
Genes - drug effects
Glucocorticoids - pharmacology
Humanities and Social Sciences
Humans
Metallothionein - genetics
Molecular and cellular biology
Molecular genetics
multidisciplinary
Mutation
Operon
Receptors, Glucocorticoid - metabolism
Science
Science (multidisciplinary)
Space life sciences
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Summary:Deletion experiments have defined two stretches of DNA (genetic elements), lying close to the promoter for a human gene for metallothionein, that separately mediate the induction of the gene by heavy metal ions, particularly cadmium, and by glucocorticoid hormones. The element responsible for induction by cadmium is duplicated, yet a single copy is fully functional; the element responsible for induction by glucocorticoid hormones is coincident with the DNA-binding site for the glucocorticoid hormone receptor.
ISSN:0028-0836
1476-4687
DOI:10.1038/308513a0