Identification of HLA-B44 subtypes associated with extended MHC haplotypes

The HLA class I antigen B44 is found in each of two different extended major histocompatibility haplotypes (allele combinations of HLA-B, HLA-DR, and complement genes BF, C2, C4A, and C4B in linkage disequilibrium). Using isoelectric focusing, two variants of HLA-B44 were identified. The basic varia...

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Bibliographic Details
Published in:Immunogenetics (New York) 1987-01, Vol.26 (4-5), p.216-219
Main Authors: KRUSKALL, M. S, EYNON, E. E, AWDEH, Z, ALPER, C. A, YUNIS, E. J
Format: Article
Language:English
Subjects:
Applied sciences
Cell Line
Exact sciences and technology
Genetic Variation
Haplotypes
HLA Antigens - classification
HLA Antigens - genetics
HLA-B Antigens
HLA-B44 Antigen
Humans
Isoelectric Focusing
Major Histocompatibility Complex
Other techniques and industries
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Summary:The HLA class I antigen B44 is found in each of two different extended major histocompatibility haplotypes (allele combinations of HLA-B, HLA-DR, and complement genes BF, C2, C4A, and C4B in linkage disequilibrium). Using isoelectric focusing, two variants of HLA-B44 were identified. The basic variant was found in all cell lines with the extended haplotype HLA-B44, DR7, FC31, and the acidic variant in all cell lines with the extended haplotype HLA-B44, DR4, SC30. The occurrence of each antigen variant with a unique extended haplotype explains previous observations concerning the nonrandom association of B44 variants with DR antigens.
ISSN:0093-7711
1432-1211
DOI:10.1007/BF00346515