The analysis and animal pharmacokinetics of 1,2,4, triglycidyl urazol using a high-pressure liquid chromatographic technique

This article details a procedure for the analysis of TGU by a simple high-pressure liquid chromatographic (HPLC) method. Linearity is maintained over the range from zero to at least 30 micrograms 1,2,4, triglycidyl urazol (TGU). The sensitivity of the assay is 250 ng/ml. A second peak, as yet uniden...

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Published in:Cancer chemotherapy and pharmacology 1984-01, Vol.12 (3), p.198-200
Main Authors: WELSH, J, STUART, J. F. B, SETANOIANS, A, BLACKIE, R. G. G, BILLIAERT, P, HALBERT, G, CALMAN, K. C
Format: Article
Language:English
Subjects:
Analysis
Animals
Biological and medical sciences
Chromatography, High Pressure Liquid - methods
Female
General pharmacology
Half-Life
Medical sciences
Mice
Pharmacology. Drug treatments
Triazines - analysis
Triazines - metabolism
Triazoles
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container_end_page 200
container_issue 3
container_start_page 198
container_title Cancer chemotherapy and pharmacology
container_volume 12
creator WELSH, J
STUART, J. F. B
SETANOIANS, A
BLACKIE, R. G. G
BILLIAERT, P
HALBERT, G
CALMAN, K. C
description This article details a procedure for the analysis of TGU by a simple high-pressure liquid chromatographic (HPLC) method. Linearity is maintained over the range from zero to at least 30 micrograms 1,2,4, triglycidyl urazol (TGU). The sensitivity of the assay is 250 ng/ml. A second peak, as yet unidentified, was detected on the chromatogram and probably represents a metabolite of TGU. The pharmacokinetic profile of TGU in Porton mice shows a first-order elimination process with a half-life (t1/2 alpha) of 1.5 min for the distribution phase and a t1/2 beta of 5 min. The apparent volume of distribution is 0.75 ml and the clearance 0.10 ml/min with a elimination rate constant of 0.14 min.
doi_str_mv 10.1007/BF00256546
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subjects Analysis
Animals
Biological and medical sciences
Chromatography, High Pressure Liquid - methods
Female
General pharmacology
Half-Life
Medical sciences
Mice
Pharmacology. Drug treatments
Triazines - analysis
Triazines - metabolism
Triazoles
title The analysis and animal pharmacokinetics of 1,2,4, triglycidyl urazol using a high-pressure liquid chromatographic technique
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