Pre- and post-operative changes in serum immunoglobulin level in neurosurgical patients

46 patients treated by operative neurosurgery for spontaneous subarachnoid haemorrhage, intracranial tumour and spinal diseases were studied. Levels of circulating immunoglobulin and complement were measured pre-operatively and serially in the first 10 post-operative days. Prior to operation immunog...

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Bibliographic Details
Published in:Acta neurochirurgica 1984-09, Vol.70 (3-4), p.269-274
Main Authors: SEELDRAYERS, P. A, HOYLE, N. R, THOMAS, D. G. T
Format: Article
Language:English
Subjects:
Biological and medical sciences
Complement C3 - analysis
Female
Humans
Immunoglobulin A - analysis
Immunoglobulin G - analysis
Immunoglobulin M - analysis
Male
Medical sciences
Middle Aged
Nervous System Diseases - blood
Nervous System Diseases - surgery
Postoperative Period
Preoperative Care
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the respiratory system
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Description
Summary:46 patients treated by operative neurosurgery for spontaneous subarachnoid haemorrhage, intracranial tumour and spinal diseases were studied. Levels of circulating immunoglobulin and complement were measured pre-operatively and serially in the first 10 post-operative days. Prior to operation immunoglobulin levels in all categories of patients were distributed normally. However, immediately post-operatively IgG and IgM fell sharply. Conversely IgA rose in a marked manner and C3 levels showed a gradual increase. Later, antibody levels tended to return to normal.
ISSN:0001-6268
0942-0940
DOI:10.1007/BF01406655