Enantiomers of 1-ethyl-7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8-difluoro-1,4- dihydro-4-oxo-3-quinoline-carboxylic acid: preparation and biological activity

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Bibliographic Details
Published in:Journal of medicinal chemistry 1987-10, Vol.30 (10), p.1711-1715
Main Authors: Culbertson, T P, Domagala, J M, Nichols, J B, Priebe, S, Skeean, R W
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - chemical synthesis
Anti-Bacterial Agents - pharmacology
Escherichia coli - drug effects
Escherichia coli - enzymology
Female
Fluoroquinolones
Mice
Microbial Sensitivity Tests
Quinolines - chemical synthesis
Quinolines - pharmacology
Staphylococcus aureus - drug effects
Stereoisomerism
Streptococcus pneumoniae - drug effects
Structure-Activity Relationship
Topoisomerase II Inhibitors
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ISSN:0022-2623