Acetylator phenotypes: effect of age

The distribution of acetylator phenotypes in a Hungarian population of 253 Caucasian was studied. The patients were divided into two age groups - the elderly over 60 years, and young below that age. The individuals below the age of 60 years contained an equal proportion of the two acetylator phenoty...

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Bibliographic Details
Published in:European journal of clinical pharmacology 1984, Vol.26 (1), p.43-45
Main Authors: GACHALYI, B, VAS, A, HAJOS, P, KALDOR, A
Format: Article
Language:English
Subjects:
Acetylation
Adult
Aged
Aging
Biological and medical sciences
Chemistry, Organic
Female
General pharmacology
Humans
Hungary
Kinetics
Male
Medical sciences
Middle Aged
Organic Chemistry Phenomena
Pharmacology. Drug treatments
Phenotype
Physicochemical properties. Structure-activity relationships
Sulfamethazine - blood
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Summary:The distribution of acetylator phenotypes in a Hungarian population of 253 Caucasian was studied. The patients were divided into two age groups - the elderly over 60 years, and young below that age. The individuals below the age of 60 years contained an equal proportion of the two acetylator phenotypes. The same distribution was observed in the population as a whole. In the elderly subjects the slow acetylator phenotype was predominant. The finding supports the hypothesis that age has an influence on hepatic drug acetylation rate.
ISSN:0031-6970
1432-1041
DOI:10.1007/BF00546707