Serial passage of tumors in mice in the study of tumor progression and testing of antineoplastic drugs

AKR lymphoma cells derived from spontaneous tumors were serially transplanted at identical inocula. The degree of malignancy and sensitivity to the polysaccharide levan and methotrexate were tested at each transfer by assessing the lag of development of primary and distant tumors and survival of mic...

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Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 1984-05, Vol.44 (5), p.1981-1984
Main Author: LEIBOVICI, J
Format: Article
Language:English
Subjects:
Animals
Antineoplastic agents
Biological and medical sciences
Cell Division - drug effects
Cell Survival - drug effects
Drug Evaluation, Preclinical - methods
Fructans - therapeutic use
General aspects
Lymphoma - drug therapy
Lymphoma - physiopathology
Male
Medical sciences
Methotrexate - therapeutic use
Mice
Mice, Inbred AKR
Neoplasm Transplantation
Pharmacology. Drug treatments
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Summary:AKR lymphoma cells derived from spontaneous tumors were serially transplanted at identical inocula. The degree of malignancy and sensitivity to the polysaccharide levan and methotrexate were tested at each transfer by assessing the lag of development of primary and distant tumors and survival of mice. A progressive increase in malignancy, accompanied by a loss of sensitivity to levan, were observed following serial passage of the lymphoma. Sensitivity to methotrexate was not affected. It is reasoned that, since serial passages permit a longer exposure of the tumor cells to selective forces of the internal milieu of the organism, better reflecting the situation in a long-life span animal, spontaneous and serial-passage tumors could serve as models for cancer therapy in humans.
ISSN:0008-5472
1538-7445